Mechanical fingerprints of pathological changes in tissue samples

Various research has demonstrated that mechanical properties of pathologically altered tissues can be useful to develop non-labelled biomarkers of distinct diseases. One of such disease is a muscular dystrophy that affects the mechanical properties of muscles.

Effect of cytochalasin D on muscle stiffness. Normalized Young’s modulus value distributions performed on thick longitudinal sections of (A) wild-type (NTOT = 126) or (B) dystrophic (NTOT = 150) mice muscle (black bars) are shown in comparison with those obtained from an adjacent section of the same muscle treated with cytochalasin D (gray bars, NTOT = 192 and NTOT = 168, respectively). The distributions werefitted with Gaussian curves, where the centers of distribution denote the Young’s modulus mean value (Puttini et al. Mol. Ther. 2009)

Our studies of mechanical properties of various tissues samples originating from distinct pathologies are oriented towards development of non-labelled biomarkers of specific diseases.