The objectives of the project are:
Objective 1. To develop and investigate a novel generation of the microfluidic devices combined with microarrays approach and with surfaces of biomimetic hydrogels to select a particular cell population.
Objective 2. To understand the mechanisms of viscoelastic changes in cells flowing through microfluidic channels by using model substances of various rheological properties.
Objective 3. To determine mechanical/rheological properties of cells used further to define criteria for effective recognition of altered cells.
Objective 4. To determine the biomechanical detectability level in cancer cell systems characterized by a large and small deformability difference.